![]() ![]() The precise mechanism of action of the drug is not known. Plasmodium falciparum 1 1 Doxycycline has been found to be active against the asexual erythrocytic forms of Plasmodium falciparum, but not against the gametocytes of P. Nocardiae and other aerobic Actinomyces species Streptococcus pneumoniae Anaerobic Bacteria Antimicrobial Activityĭoxycycline has been shown to be active against most isolates of the following microorganisms, both in vitro and in clinical infections as described in the INDICATIONS AND USAGE section of the package insert. ResistanceĬross resistance with other tetracyclines is common. Doxycycline has bacteriostatic activity against a broad range of Gram-positive and Gram-negative bacteria. Microbiology Mechanism of Actionĭoxycycline inhibits bacterial protein synthesis by binding to the 30S ribosomal subunit. Results of animal studies indicate that tetracyclines cross the placenta and are found in fetal tissues. Hemodialysis does not alter serum half-life. Studies have shown no significant difference in serum half-life of doxycycline (range 18–22 hours) in individuals with normal and severely impaired renal function. This percentage excretion may fall as low as 1 to 5%/72 hours in individuals with severe renal insufficiency (creatinine clearance below 10 mL/min.). Excretion of doxycycline by the kidney is about 40%/72 hours in individuals with normal function (creatinine clearance about 75 mL/min.). Doxycycline is virtually completely absorbed after oral administration.įollowing a 200 mg dose, normal adult volunteers averaged peak serum levels of 2.6 mcg/mL of doxycycline at 2 hours, decreasing to 1.45 mcg/mL at 24 hours. They are concentrated by the liver in the bile, and excreted in the urine and feces at high concentrations and in a biologically active form. Tetracyclines are readily absorbed and are bound to plasma proteins in varying degree. Related/similar drugs prednisone, amoxicillin, albuterol, doxycycline, ciprofloxacin, metronidazole, metronidazole topical Doxycycline Oral Suspension - Clinical Pharmacology Each tablet, for oral administration, contains doxycycline hyclate equivalent to 100 mg doxycycline. 6, hypromellose, magnesium stearate, methylcellulose, microcrystalline cellulose, polyethylene glycol, sodium starch glycolate, stearic acid, and titanium dioxide. Inactive ingredients for the tablet formulation are: anhydrous lactose, colloidal silicon dioxide, FD&C Red No. When reconstituted, each teaspoonful (5 mL) doxycycline suspension, for oral administration, contains doxycycline monohydrate equivalent to 25 mg of doxycycline. Inactive ingredients for the oral suspension formulation are: confectioner's sugar, D&C red #27 aluminum lake, ethyl acetate, maltodextrin, methylparaben, microcrystalline cellulose/ sodium carboxymethylcellulose, modified cornstarch, natural flavoring propylparaben, simethicone and sucrose. Each capsule, for oral administration, contains doxycycline hyclate equivalent to 50 mg or 100 mg of doxycycline. Black ink contains shellac glaze in SD-45, black iron oxide, propylene glycol, FD&C Blue #2, FD&C Red # 40, FD&C Blue # 1, D&C Yellow # 10, butyl alcohol, denatured alcohol. 100 mg gelatin capsule shell contains: FD&C Blue #1, titanium dioxide and gelatin. 50 mg gelatin capsule shell contains: FD&C Blue #1, D&C Yellow #10, titanium dioxide and gelatin. Inactive ingredients in the capsule formulations are: colloidal silicon dioxide, lactose anhydrous, magnesium stearate, methylcellulose, microcrystalline cellulose, polyethylene glycol, sodium starch glycolate, and stearic acid. Doxycycline will not degrade into an epianhydro form. It is highly stable in normal human serum. ![]() Doxycycline hyclate is soluble in water, while doxycycline monohydrate is very slightly soluble in water.ĭoxycycline has a high degree of lipoid solubility and a low affinity for calcium binding. Doxycycline is a light-yellow crystalline powder. The molecular formula for doxycycline hydrochloride hemiethanolate hemihydrate is (C 22H 24N 2O 8∙HCl) 2∙C 2H 6O∙H 2O and the molecular weight is 1025.89. The chemical designation for doxycycline is 4-(Dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,5,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-2-naphthacenecarboxamide monohydrate. With a molecular formula of C 22H 24N 2O 8∙H 2O and a molecular weight of 462.46. The structural formula of doxycycline monohydrate is Doxycycline Oral Suspension Descriptionĭoxycycline is an antibacterial drug synthetically derived from oxytetracycline, and is available as Doxycycline Hyclate Tablets and Capsules and Doxycycline for Oral Suspension for oral administration. To reduce the development of drug-resistant bacteria and maintain the effectiveness of Doxycycline and other antibacterial drugs, doxycycline should be used only to treat or prevent infections that are proven or strongly suspected to be caused by bacteria. ![]()
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